Protein kinase B

Protein kinase B

It first came to prominence... in the mid 1990s, when it was shown that PKB is regulated by PI 3-kinase, a lipid kinase that everyone was trying to find effectors for. Is that it? No. The really big excitement came when it transpired that PKB, through the actions of PI 3-kinase, transmits a survival signal that allows cells to suppress apoptosis. Strangely, only two studies have shown a direct ...

Active Protein Kinase B Regulates TCR

Physiological functions of protein kinase B/Akt.

The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotyp...

Protein kinase B/Akt at a glance.

Among the signalling proteins that respond to a large variety of signals, protein kinase B (PKB, also known as Akt) appears to be a central player in regulation of metabolism, cell survival, motility, transcription and cell-cycle progression. Conserved from primitive metazoans to humans, PKB belongs to the AGC subfamily of the protein kinase superfamily, which consists of 518 members in humans ...

berberine induced apoptosis of human osteosarcoma cells by inhibiting phosphoinositide 3 kinase/protein kinase b (pi3k/akt) signal pathway activation

background: osteosarcoma is a malignant tumor with high mortality but effective therapy has not yet been developed. berberine, an isoquinoline alkaloid component in several chinese herbs including huanglian, has been shown to induce growth inhibition and the apoptosis of certain cancer cells. the aim of this study was to determine the role of berberine on human osteosarcoma cell lines u2os and ...